REALQUALITY ResP-RhinEV

Description

REALQUALITY ResP-RhinEV is an IVD for the identification of Rhinovirus and/or Enterovirus by Real-Time PCR

Product Characteristics

• The device is validated on RNA extracted from various samples types
• The assay requires only 5 µL of RNA extracted
• Validated on main Real time PCR instruments
• The automatic format of the assay can be used used on GENEQUALITY® automatic platforms
• Easy interpretation of results with AB Genius Report software

Kit content

Kit content:

• Freeze-dried reagents for real time PCR amplification
• Extraction control (freeze-dried)
• Positive control (freeze-dried)
• Negative control
• Rehydration Buffer (solution to reconstitute the freeze-dried products)
• Water RNAse/DNAse free

Further Information

Human rhinoviruses (HRV) and human enteroviruses (HEV) are the most common cause of human infections worldwide. They belong to the genus Enterovirus, family Picornaviridae. The Picornaviridae family includes causative agents of a wide variety of diseases ranging from the common cold poliomyelitis and aseptic meningitis.

Rhinovirus infections are usually relatively trivial and not life-threatening. Rhinovirus infection is usually accompanied by symptoms of the common cold. These vary according to the individual and possibly the particular rhinovirus, but usually include nasal discharge and obstruction, often with sneezing, coughing and sore throat. Fever and malaise are less common than infections with other respiratory viruses, but gastrointestinal disturbances are not uncommon, especially in children.
Although limited largely to the upper respiratory tract, rhinovirus infections are thought to predispose some individuals to bacterial sinusitis and otitis media. Additionally, rhinoviruses can produce severe and debilitating lower respiratory tract infections, particularly in the elderly, young children, and patients with pre-existing disorders, such as cystic fibrosis and bronchopulmonary dysplasia.

Enterovirus is the usual cause of the common cold, but is also frequently found in otitis media, sinusitis, bronchitis, pneumonia, and exacerbations of asthma. Unlike HRVs, HEV replication is not limited to the respiratory tract, but can also occur in the small intestine and spread to various target organs. They are easily transmitted from person to person by airborne and/or fecal-oral route, or even through contaminated objects. Most HEV infections are either asymptomatic or have common cold-like symptoms. However, HEV infections can be more severe, causing polio, meningitis, encephalitis, myocarditis, exanthema, acute hemorrhagic conjunctivitis, and severe generalized infections in newborns.

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