Author Archives: AB Analitica

ADLM 2024

AB ANALITICA will be attending the AACC Annual Scientific Meeting organized annually by ADLM – Association for Diagnostics & Laboratory Medicine to be held from July 28 to August 1, 2024 in Chicago IL, USA.

Come and visit us at Booth 4953 to learn more about our products, we look forward to seeing you!

https://meeting.myadlm.org

ECCMID 2024

AB ANALITICA will be attending the 33rd ECCMID International Congress – European Congress of Microbiology and Infectious Diseases organized annually by ESCMID to be held from April 27 to 30, 2024 in Barcelona, Spain.

Come and visit us at Booth E70 to learn more about our products, we look forward to seeing you!

Discover the revolutionary platform Sample To Result GENEQUALITY® 2050

GQ 2050 is a fully integrated Real-Time PCR system capable of performing all stages without the need for operator intervention.

The GENEQUALITY® TWENTYFIFTY (GQ 2050) is an automated sample-to-result system, with integrated thermal cycler, for the extraction of nucleic acids from biological samples, the Real-Time PCR reactions set-up and run and the reporting of the results..

Product Characteristics

  • Extraction of DNA and RNA from different matrices in the same analytical run, starting from the primary tube.
  • Quick extraction system with magnetic rod system.
  • Full traceability of the entire workflow.
  • Software with touch screen interface configurable in different languages.
  • Decontamination control with the integrated UV lamp.
  • Bidirectional interface to the laboratory management system.
  • Up to 32 biological samples processed simultaneously from primary tubes.
  • Sample carriers capable of accommodating primary tubes with diameters from 11 to 16 mm and heights from 65 to 105 mm.
  • Up to 24 different Real-Time PCR reactions.
  • Active cooling block for Real-Time PCR reagents.
  • Software for automatic processing of Real-Time PCR data.

Further Information

The system presents several control and safety features including:+

  • 1 air displacement channel with volume range up to 1000 μL, barometric and capacitive liquid sensor, and clot detection;
  • Control of heating block temperatures;
  • A camera system that assists the operator during the instrument loading.

Additionally, the GQ 2050 is equipped with a Hepa filter for environmental safety, UV lamp and tips with filters to manage and limit potential contaminations.

See product

AMCLI 2024

AB ANALITICA will be attending the 51st AMCLI Congress in Rimini from March 8 to 11, 2024.
We invite you to our stand to see our products in person and meet our team.

This year we have exciting news… are you ready to discover it?
It will be a great opportunity to see us in person, we look forward to seeing you!

XLII Congresso Nazionale AMCLI (Rimini, 12-15 Novembre 2013)-1

Poster (cod.157): “Sviluppo e validazione di un nuovo test molecolare per l’identificazione simultanea di polimorfismi nei geni IL28B e ITPA, implicati nel trattamento farmacologico dell’epatite C”.
Autori: Bortolozzo K., Bugin E., Rosa Gastaldo L., Marcolongo M., Gonzo M., Paladin D.
Prodotto citato / Cited product: GENEQUALITY IL28B-ITPA TYPE

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Tesi di Dottorato di Ricerca in Scienze Farmacologiche, XXVI ciclo,a.a. 2012-2013. Indirizzo: Farmacologia Molecolare e Cellulare Università degli Studi di Padova

“WARFARIN E PEG-IFN/RBV: Sviluppo di Test Farmacogenetici per la Personalizzazione della Terapia Farmacologica”
Dottoranda: Elisabetta Bugin
Direttore della Scuola: Ch.mo Prof. Pietro Giusti
Coordinatore di Indirizzo: Ch.mo Prof. Pietro Giusti
Supervisore Interno: Ch.mo Prof. Eugenio Ragazzi, Supervisore Esterno: Dott. Dino Paladin
Prodotti citati / Cited products: GENEQUALITY AB WARFARIN TYPE

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II CONGRESSO Nazionale Nuove tecnologie di medicina personalizzata nell’era post-genomica (Padova, 13 Settembre 2013)

Poster: WARFARIN TYPE: Sviluppo di un test farmacogenetico per il dosaggio individuale del Warfarin(Coumadin®)
E.Bugin, K.Bortolozzo, D.Paladin, M.Pelloso, S.Moz, D.Bozzato, P.Fogar, D.Basso, CF.Zambon, M.Plebani.
Prodotto citato / Cited product: GENEQUALITY AB WARFARIN TYPE

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Clin Chem Lab Med. 2014 Jun;52(6) Abstract P2

Poster presentation at: ISMD2014 10th International Symposium on Molecular Diagnostics (May 29 – 31, 2014)
Poster (P2): “Novel pharmacogenetic test for management of antiviral therapy in patients with chronic hepatitis C”.
Bugin E., Cavalletto L., Bortolozzo K., Schiavo I., Chemello L.
Prodotto citato / Cited product: GENEQUALITY IL28B-ITPA TYPE

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1° CONGRESSO NEWMICRO – Biotecnologie e diagnostica molecolare nella diagnosi delle malattie infettive (Trento 19-21 gennaio 2011)

Poster : “A New and Simple Method for HLA-B*57:01 Screening Before ABACAVIR Treatment”
Autori: Bortolozzo K.; Boschetto C., Hajman K., Cesaro L., Mason S, Baroncelli M., Sestini R., Porfirio B.
Prodotto citato / Cited product: GENEQUALITY HLA B*57-01

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20th IFCC-EFLM European Congress of Clinical Chemistry and Laboratory Medicine 45th Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology (SIBioC)

WINNER OF POSTER AWARDS COMPETION AT EUROMEDLAB MILANO 2013:
Atypical Cystic Fibrosis: development of a new genetic test for identification of ENaC mutations
Renesto, A., Bortolozzo, K., Albanese, A., Tamanini, A., Zampieri, C., Dechecchi, M. C.

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La Rivista Italiana della Medicina di Laboratorio – Italian Journal of Laboratory Medicine, RIMeL/IJLaM 2009; 5 (Suppl.). Atti del 23° Congresso Naz. SIMEL – 2° Evento Naz Congiunto SiBioC-SIMeL. p192, F-87

Screening per le mutazioni del gene CFTR (Cystic Fybrosis transmembrane regulator gene) in 3.578 pazienti infertili candidati per tecniche di riproduzione assistita e relazione tra le mutazioni del cromosoma Y in maschi azoospermici.
M.Rongioletti, F.Papa, M.Cortesi, L.Bonito, V.Panetta, C.Vaccarella, T.Melillo, B.D’Andrea, P.Scotaccia, S.Cesaretta, G.M.Liumbruno.
Prodotti citati / Cited products: GENEQUALITY AZF MX

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Tissue Antigens, 2010 75 (5). Abstracts of the 24th European Immunogenetics and Histocompatibility Conference 17th Annual Meeting of the Italian Society for Immunogenetics and Transplantation Biology – Florence, Italy May 15-18, 2010 (www.efi2010.eu)

Poster presentation (P118): “A new simple method for HLA-B*5701 screening before abacavir treatment”
K.Bortolozzo, C.Boschetto, K.Hajman, L.Cesaro, S.Mason, M.Baroncelli, R.Sestini, B.Porfirio.
Prodotto citato / Cited product: GENEQUALITY HLA B*57-01

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XXXVIII Congresso Nazionale AMCLI Rimini, 20-22 Ottobre 2010

Comunicazione orale: “Evaluation of AMPLIQUALITY HCV-TS Kit for Direct Genotyping on Amplicons Obtained by COBAS TAQMAN HCV TEST”.
Bortolozzo K.; Hajman K.; Rosa Gastaldo L.; Renesto A.; Rovinetti C.; Turi R.; Ceres A.; Capone G.; Mirandola S.; Marcolongo M.; Alberti A.; Bassetti D.; Collini L.; Lanzafame P., Bevilacqua F.
Prodotto citato / cited Product: AMPLIQUALITY HCV-TS

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1° CONGRESSO NEWMICRO – Biotecnologie e diagnostica molecolare nella diagnosi delle malattie infettive (Trento 19-21 gennaio 2011)-1

Poster : “Valutazione del Kit per la Genotipizzazione Diretta da Amplificato COBAS® TAQMAN® HCV Test”
Autori: Bortolozzo K.; Hajman K.; Rosa Gastaldo L.; Renesto A.; Pelizzaro R., Rovinetti C.; Turi R.; Ceres A.; Capone G.; Mirandola S.; Marcolongo M.; Alberti A.; Bassetti D.; Collini L.; Lanzafame P.,Veronesi A., Scapin L.,Bevilacqua F.
Prodotto citato / Cited product: AMPLIQUALITY HCV TS

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IFCC WorldLab Istanbul 2014 (22-26 June 2014, Istanbul, Turkey)-1

Poster presentation: ” Plasminogen Activator Inhibitor-1 gene 4G/5G polymorphism in group of Serbian women with primary and secondary infertility”.
Simic Svetlana, Stevanovic Snezana, Brajic Aleksandra, Djurovic Jelena, Stamenkovic Gorana.
Prodotto citato / Cited product: REALQUALITY RS-PAI-1 4G/5G

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IFCC WorldLab Istanbul 2014 (22-26 June 2014, Istanbul, Turkey)-2

Poster presentation: “Impact of C677T polymorphism of the methylenetetrahydrofolate reductase in group of Serbian women with primary and secondary infertility”.
Brajic Aleksandra, Vuksanovic Ana, Sarkic Mirjana, Ckonjovic Miodrag, Stamenković Gorana.
Prodotto citato / Cited product: REALQUALITY RS-MTHFR C677T

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XLII Congresso Nazionale AMCLI (Rimini, 12-15 Novembre 2013)-1

Poster (cod.157): “Sviluppo e validazione di un nuovo test molecolare per l’identificazione simultanea di polimorfismi nei geni IL28B e ITPA, implicati nel trattamento farmacologico dell’epatite C”.
Autori: Bortolozzo K., Bugin E., Rosa Gastaldo L., Marcolongo M., Gonzo M., Paladin D.
Prodotto citato / Cited product: GENEQUALITY IL28B-ITPA TYPE

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Tesi di Dottorato di Ricerca in Scienze Farmacologiche, XXVI ciclo,a.a. 2012-2013. Indirizzo: Farmacologia Molecolare e Cellulare Università degli Studi di Padova

“WARFARIN E PEG-IFN/RBV: Sviluppo di Test Farmacogenetici per la Personalizzazione della Terapia Farmacologica”
Dottoranda: Elisabetta Bugin
Direttore della Scuola: Ch.mo Prof. Pietro Giusti
Coordinatore di Indirizzo: Ch.mo Prof. Pietro Giusti
Supervisore Interno: Ch.mo Prof. Eugenio Ragazzi, Supervisore Esterno: Dott. Dino Paladin
Prodotti citati / Cited products: GENEQUALITY AB WARFARIN TYPE

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II CONGRESSO Nazionale Nuove tecnologie di medicina personalizzata nell’era post-genomica (Padova, 13 Settembre 2013)

Poster: WARFARIN TYPE: Sviluppo di un test farmacogenetico per il dosaggio individuale del Warfarin(Coumadin®)
E.Bugin, K.Bortolozzo, D.Paladin, M.Pelloso, S.Moz, D.Bozzato, P.Fogar, D.Basso, CF.Zambon, M.Plebani.
Prodotto citato / Cited product: GENEQUALITY AB WARFARIN TYPE

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Clin Chem Lab Med. 2014 Jun;52(6) Abstract P2

Poster presentation at: ISMD2014 10th International Symposium on Molecular Diagnostics (May 29 – 31, 2014)
Poster (P2): “Novel pharmacogenetic test for management of antiviral therapy in patients with chronic hepatitis C”.
Bugin E., Cavalletto L., Bortolozzo K., Schiavo I., Chemello L.
Prodotto citato / Cited product: GENEQUALITY IL28B-ITPA TYPE

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ESPT 2nd Summer School on Pharmacogenomics and Theranostics (Roma, 9-14 Giugno 2014)

Poster presentation: “Development of two diagnostic systems for the detecion of mutations in the genes MPL and CALR”.
Schiavo I., Anselmi A. Costanzi G., Guglielmelli P., Pancrazzi A., Paladin D., Vannucchi AM.
Prodotto citato / Cited product: GENEQUALITY CALR MUTATION

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XLIII Congresso Nazionale AMCLI (Rimini, 4-7 Novembre 2014)

Poster (cod.164): “Valutazione degli IVD REALQUALITY RQ-STI AB ANALITICA nella diagnosi delle infezioni sessualmente trasmesse”.
Autori: Dirani G., Dalmo B., Strammiello R., Sambri V. Farabegoli P.
Prodotti citati / Cited products: REALQUALITY RQ-STI CT/NG, REALQUALITY RQ-STI MG/MH, REALQUALITY RQ-STI UU/UP

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16th European Congress of Clinical Microbiology and Infectious Diseases (ESMID) – Nice, France, April 1-4 2006. Abstract number: p1694 in: Clin Microbiol Infect. 2006 (12) S4, P1694

Prevalence of Helicobacter pylori oral carriage in a children’s community
De Vito D., Santantonio M., Coscia M.F., Rizzo C., Monno R.A., Rizzo G.
Prodotto citato/Cited product: AMPLIQUALITY HP

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J. Med. Virol., 2013, 85: 888-892. doi: 10.1002jmv.23499

Frequent detection of cytomegalovirus (CMV) DNA in the lower respiratory tract in CMV-seropositive pediatric patients with underlying chronic bronchopulmonary diseases lacking canonical immunosuppression.
Escribano, A., Chilet, M., Clari, M. Á., Lucas, R., Costa, E., Bravo, D., Muñoz-Cobo, B., Borrás, R. and Navarro, D.
Prodotto citato / cited Product: REALQUALITY RS-HHV-7, REALQUALITY RS-HHV-8

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Tesi di Laurea in Biologia Molecolare, Università degli Studi di Padova, Dipartimento di Istologia, Microbiologia e Biotecnologie Mediche, a.a. 2010/2011

Ricerca di Chlamydia trachomatis in pazienti HPV positivi e HPV negativi.
Laureanda: Lisa Fabrello;
Relatore:Prof. Giulio Bertoloni ,
Co- Tutor: Dott. Roberto Marcante – U.L.S.S. n. 4 “Alto Vicentino
Prodotti citati / Cited products: REALQUALITY RS-CHLAM T

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1° CONGRESSO NEWMICRO – Biotecnologie e diagnostica molecolare nella diagnosi delle malattie infettive (Trento 19-21 gennaio 2011)-3

Workshop teorico-pratico: “Nuovo approccio di screening e tipizzazione del Papilloma Virus Umano”
Relatore: Mason S.; Lapucci C.
Prodotti citati / Cited products: REALQUALITY RI-HPV STAR, AMPLIQUALITY HPV TYPE HR

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20th ECCMID (10 – 13 April 2010) Vienna, Austria. ABSTRACT R2208 in: Clinical Microbiology and Infection, 16 April 2010, p S660

Prevalence and type distribution of Human Papillomaviruses types in women with abnormal cytology results in Greece.
I. Dendrinos, E.T. Piperaki, N. Spanakis, V. Pitiriga, A. Antsaklis,A. Tsakris.
Prodotti citati / cited Products: AMPLIQUALITY HPV HS BIO, AMPLIQUALITY HPV TYPE

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1° CONGRESSO NEWMICRO – Biotecnologie e diagnostica molecolare nella diagnosi delle malattie infettive (Trento 19-21 gennaio 2011)-2

Poster : “Ricerca del Papilloma Virus Umano in Campioni Istologici Mediante Real Time PCR”
Autori: Piovan M., Pomarè Montin D., Mason S., Gani A., Bortolozzo K., Brusauro F., Lapucci C.
Prodotti citati / Cited products: REALQUALITY RI-HPV STAR, AMPLIQUALITY HPV TYPE HR

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Tesi di Laurea I° liv. Biotecnologie Sanitarie, Università degli Sudi di Padova, a.a. 2006-7

“La Diagnostica Del Papilloma Virus Umano: Metodi Molecolari a Confronto”
Laureanda: Valentina Griggio; Relatore: Prof.A.Negro; Correlatore: dott.ssa K.Bortolozzo.
Prodotti citati / Cited products: AMPLIQUALITY HPV HS Bio, AMPLIQUALITY HPV TYPE

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Tesi di Dottorato di Ricerca in Oncologia e Oncologia Chirurgica XXI ciclo, Università degli Sudi di Padova, a.a. 2009

“HPV e Carcinoma della Cervice Uterina”
Dottoranda: H. Frayle Salamanca. Coordinatore: Ch.ma Prof.ssa P. Zanovello, Supervisore: Ch.ma Dott.ssa A. Del Mistro
Prodotti citati / Cited products: AMPLIQUALITY HPV HS Bio, AMPLIQUALITY HPV TYPE

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Clin Chem Lab Med 2012; 50(4), A76-77

Abstract A12 :Comparison of a novel Real Time PCR/Reverse Line Blot-based technique and the digene HC2 Assay for detection of high-risk HPV genotypes in cervical samples.
S Mason, A Gani, M Vettorato, G Negri, C Mian, F Brusauro, K Bortolozzo
Oral presentation at: ISMD 2012 – Ninth International Symposium on Molecular Diagnostics, Campus of University of Graz, RESOWI-Center (CE), 17-19 Maggio 2012.
Prodotti citati / cited products: REALQUALITY RI HPV STAR, AMPLIQUALITY HPV TYPE

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Tesi di Dottorato di Ricerca in Scienze Endocrinologiche, Metaboliche ed Andrologiche XXVI Ciclo, a.a. 2012-2013

Ruolo dell’HPV nell’Infertilità Maschile
Dottorando: Dott. Damiano Pizzol, Tutor: Prof.ssa Loredana Gandini, Prof.Carlo Foresta
Dipart.Medicina Sperimentale, Università degli Studi di Roma “La Sapienza”.
Prodotti citati / cited products: AMPLIQUALITY HPV-TYPE EXPRESS V3.0

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XLII Congresso Nazionale AMCLI (Rimini, 12-15 Novembre 2013)-2

Poster nr 156: “Identificazione e tipizzazione del Papillomavirus Umano: sviluppo di un nuovo test molecolare”.
Autori: Mason S., Brusauro F., Gani A., Stellin I., Turconi P., Acciai F., Bortolozzo K.
Prodotti citati / cited Products: AMPLIQUALITY HPV-TYPE EXPRESS V3.0, AMPLIQUALITY HPV-TYPE HS BIO

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Congresso Internazionale EUROGIN 2013 (Firenze, 3-6 Novembre 2013)

Poster (P4-4): “Comparison between nested and single-step PCR for high sensitivity detection of Human Papillomavirus”
Autori: Mason S, Brusauro F, Gani A, Stellin I, Bortolozzo K.
Prodotti citati / cited Products: AMPLIQUALITY HPV-TYPE EXPRESS V3.0, AMPLIQUALITY HPV-TYPE HS BIO

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Tesi di Laurea Magistrale in Biologia Molecolare, Università degli Studi di Padova, a.a. 2012/2013

Identificazione e tipizzazione del Papillomavirus Umano (HPV): sviluppo di un nuovo test molecolare.
Laureanda: Ilaria Stellin; Relatore: Prof. Andrea Trevisan, Correlatore: Dr.ssa Silvia Mason, Dr.ssa Federica Brusauro
Prodotti citati / cited products: AMPLIQUALITY HPV-TYPE EXPRESS, AMPLIQUALITY HPV-TYPE HR

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Pathologica 2012; 104,164

Abstract 164: Detection of high-risk HPV genotypes in cervical samples: a comparison study of a novel Real Time PCR/Reverse Line Blot-based technique and the digene HC2 Assay.
S Mason, A Gani, M Vettorato, G Negri, C Mian, F Brusauro, K Bortolozzo
Poster presentation at: Congresso Nazionale di Citopatologia SIAPEC – IAP, Trieste, 28-30 giugno 2012
Prodotti citati / cited products: REALQUALITY RI HPV STAR, AMPLIQUALITY HPV TYPE

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Tesi di Laurea Magistrale in Biologia della Salute, Alma Mater Studiorum Università di Bologna, a.a. 2011/2012

Studio comparativo sulla diagnostica molecolare delle infezioni da Papillomavirus Umano: Real Time PCR/Reverse Line Blot e Hybrid Capture 2 a confronto.
Laureanda: Marianna Vettorato; Relatore: Prof.ssa Elisa Avitabile, Correlatore: Dr.ssa Silvia Mason
Prodotti citati / cited products: REALQUALITY RI HPV STAR, AMPLIQUALITY HPV TYPE, AMPLIQUALITY HPV SM

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Clin Biochem. 2004 Apr;37(4):261-7

Non-invasive diagnosis of Helicobacter pylori infection: simplified 13C-urea breath test, stool antigen testing, or DNA PCR in human feces in a clinical laboratory setting?
Zambon CF, Basso D, Navaglia F, Mazza S, Razetti M, Fogar P, Greco E, Gallo N, Farinati F, Rugge M, Plebani M.
Prodotto citato / Cited product: BREATHQUALITY UBT

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Aliment Pharmacol Ther. 2005 Oct 15;22(8):715-20

DNA sequences and proteic antigens of H. pylori in cholecystic bile and tissue of patients with gallstones.
Neri V, Margiotta M, de Francesco V, Ambrosi A, Valle ND, Fersini A, Tartaglia N, Minenna MF, Ricciardelli C, Giorgio F, Panella C, Ierardi E.
Prodotto citato / Cited product: BREATHQUALITY UBT (cod 11-75)

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La Rivista Italiana della Medicina di Laboratorio – Italian Journal of Laboratory Medicine, RIMeL/IJLaM 2006; 2 (Suppl.). Atti del 20° Congresso Naz. SIMEL p153, B-02

Infezioni da H.pylori associate a Tiroidite ed Orticaria Cronica: follow-up con urea breathtest e spettrometria di massa isotopica.
C.D’Amario, A.Di Sante, G.Fiore, M.Cervone, B.Raggiunti.
Prodotto citato / Cited product: BREATHQUALITY UBT (cod 11-75)

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Journal of Gastrointestinal Surgery 2007; 11(11) 1506-14

Clarithromycin Resistance, Tumor Necrosis Factor Alpha Gene Polymorphism and Mucosal Inflammation Affect H. pylori Eradication Success
Zambon CF, Fasolo M, Basso D, D’Odorico A, Stranges A, Navaglia F, Fogar P, Greco E, Schiavon S, Padoan A, Fadi E, Sturniolo GC, Plebani M, Pedrazzoli S.
Prodotto citato / Cited product: BREATHQUALITY UBT (cod 11-75)

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Helicobacter. 2008 Apr;13(2):127-34

Inhibition of Helicobacter pilori Infection in Humans by Lactobacillus reuteri ATCC 55730 and Effect on Eradication Therapy: A Pilot Study
Francavilla R, Lionetti E, Castellaneta SP, Magistà AM, Maurogiovanni G, Bucci N, De Canio A, Indrio F, Cavallo L, Ierardi E, Miniello VL
Prodotto citato / Cited product: BREATHQUALITY UBT (cod 11-75)

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AB ANALITICA partners in DECIDER project en

AB ANALITICA partners in DECIDER project to improve diagnostics and treatment of ovarian cancer with the help of AI – 15 mil­lion euros in fund­ing from the EU

The goal of the 5-year research project is to discover novel diagnostic tools and effective drug combinations based on data from high-grade serous ovarian cancer patients. Partners in this international and multidisciplinary project come from 14 organisations in seven EU countries.

The European Union has funded a project to improve personalized treatments for ovarian cancer with nearly 15 million euros for five years. The international DECIDER project has partners from 14 organizations in seven EU countries.

In Europe, over 40.000 women die of ovarian cancer every year. In addition to surgery, most patients are treated with platinum-based chemotherapy. Unfortunately, the effect of the chemotherapy often decreases during the treatment cycles, and currently there are few effective treatments to those patients who develop resistance to platinum-based drugs.

The project starts in February and will develop diagnostic tools to identify earlier and more reliably patients whose cancer is not responding to the current treatments. The research also aims to discover effective combination treatments based on the data measured from the tumours.

“Cancer is one of the leading causes of mortality in the world and as the population ages, the incidence of cancers will only increase. Any new tools that enable better and more targeted treatment of cancers in the future will not only decrease the amount of human suffering, but also the burden on healthcare,” says Sampsa Hautaniemi, a professor at the University of Helsinki and coordinator of the DECIDER project.

Artificial intelligence to integrate and visualise patient information for doctors

In the project, a patient’s response to treatments is predicted using methods, which use, among others, histopathological and genomic data from the patient. Genomic changes and aberrations in gene functions are used to find effective, personalized treatments.

“We will develop an open source program, which will integrate and visualize all relevant data from a patient. Using this information, doctors can more easily identify effective drugs for their patient,” says Hautaniemi, whose research group works in the project on method development as well as analysis, integration and interpretation of the data measured from the tumours.

An important part of the project is collaboration with SMEs in developing, producing and registering diagnostic kits, producing a drug-sensitivity test based on the tumour tissue samples, developing image based diagnostics of digital samples, and developing data pseudonymisation and anonymisation techniques necessary for the management of sensitive patient data for privacy risk protection.

AB ANALITICA, as a developer and manufacturer of IVD (In Vitro Diagnostics) devices compliant with the applicable regulations, consisting of reagent kits for performing nucleic acid molecular testing assays and related equipment and software, is involved in the development and subsequent production and marketing of diagnostic kits for performing the drug-sensitivity tests.

Legal researchers address ethical and legal concerns

In addition to medical research, the project also includes a legal work package that addresses the ethical and legal concerns that may arise in the project. Furthermore, the legal researchers will also study whether there are inconsistencies between the pharmaceutical regulatory system and other relevant legislation.

“Our aim is to overcome legal challenges that impede or slow down the provision of new treatments for chemotherapy resistance in high-grade serous ovarian cancer patients. We want to facilitate the commercialisation and availability of personalized therapies in an ethically and legally sustainable manner,” says Professor Päivi Korpisaari.

DECIDER partners and persons in charge of the research

DECIDER (Clinical Decision via Integrating Multiple Data Levels to Overcome Chemotherapy Resistance in High-Grade Serous Ovarian Cancer) partners and persons in charge of the research:

University of Helsinki, Finland (Sampsa Hautaniemi, Olli Carpén, Päivi Korpisaari)
Hospital District of Southwest Finland (Johanna Hynninen)
HUS Helsinki University Hospital, Finland (Anni Virtanen)
Karolinska Institutet, Sweden (Jussi Taipale)
Danish Cancer Society, Denmark (Tuula Kallunki)
Heidelberg University Hospital, Germany (Julio Saez-Rodriguez)
Institut Pasteur, France (Benno Schwikowski)
University of Modena and Reggio Emilia, Italy (Elisa Ficarra)
Insitute for Research in Biomedicine, Spain (Fran Supek)
Barcelona Supercomputing Center, Spain (Salvador Capella)
Aiforia Technologies Oy, Finland (Kaisa Helminen)
VEIL.AI Ltd, Finland (Tuomo Pentikäinen)
2cureX A/S, Denmark (Ole Thastrup)
AB ANALITICA SRL (Diego Boscarino)
In advisory role representing cancer patients viewpoint: Cancer Society of Finland and Association of Cancer Patients in Finland.

The project has been funded by European Union’s Horizon 2020 research and innovation programme under grant agreement No 965193.

Further information from:

Sampsa Hautaniemi, professor, University of Helsinki
Phone. +358 50 448 63 20
Email: sampsa.hautaniemi@helsinki.fi

Read more about the project from the DECIDER website.
Project Twitter account: @deciderproject

Interreg Italia-Slovenia

AB ANALITICA part of the decades-long cooperation with the company DOTT DINO PALADIN is pleased to announce the realization of this new Interreg Italia-Slovenija project by the company DOTT DINO PALADIN. In the future this project could give rise to a new realization of innovative in vitro devices.

Interreg Italia-Slovenija

DIAGNOSIS OF PROSTHETIC INFECTIONS IN ORTHOPEDICS WITH INNOVATIVE METHODS BASED ON THE USE OF BACTERIOPHAGES

Standard project co-financed by the European Regional Development Fund

The aim is to design a diagnostic test for bacterial detection within the sonication fluid from an infected prosthetic joint using an optimized suspension of specific phages.

The Scientific Research Center DOTT. DINO PALADIN is partner of the project.

Download the poster of the project

AB ANALITICA partner in a EU funded project for ovarian cancer research en

EU funds ovarian cancer research with 6 million euros

An international collaboration project to study drug resistance in ovarian cancer has received 6 million euros for five years from the EU Horizon 2020 Research and Innovation program. The project is coordinated from the University of Helsinki, Finland, and begins on January 1, 2016.

The HERCULES project focuses on the most common and most difficult to treat subtype of ovarian cancer, high-grade serous ovarian cancer. These tumors consist of several heterogeneous cell populations with a large number of mutations. This genetic variability of the tumors makes it difficult to find drugs that would be able to kill all the cancer cells and to which some of the cells would not become resistant during treatment.

Although most patients respond well to current treatments initially, more than half of them experience relapse. In Europe more than 40 000 women die of ovarian cancer every year.

In the HERCULES project, the tumors are analyzed in an unprecedented level of detail to discover which cell populations the tumors consist of, how they respond to treatments and what makes them resistant to treatments.

Patient samples are used to study the function of genes and proteins at a single-cell level by using the latest mass cytometry, sequencing and computational methods. The researchers aim to find an optimal set of biomarkers that can be used to identify different cell populations from tissue samples. Fresh tissue samples and cell lines will be used to study the tumor cells’ response to several drug compounds.

The results from these experiments will be used in computational modelling and development of computational tools to predict which drug compounds will target each cell population best. Based on this information, the aim is to develop a test that can be used to predict which drug combinations will be most efficient against an individual patient’s cancer.

The results of the project will help doctors in finding the best treatments to each ovarian cancer patient.

In addition to coordinating the project, University of Helsinki researchers are responsible for sample sequencing, data analysis, development of computational tools, single-cell sequencing and drug response experiments. Other partners in Finland are from the University of Turku and the Hospital District of South-West Finland. They are in charge of recruiting patients, collecting and processing the samples and establishing cell lines.

Network modeling for the project is performed at the Institute of Pasteur in France and identification and sorting of cell populations at the Istituto Superiore di Sanità in Italy. Gene regulation and expression studies are done at the Karolinska Institutet in Sweden. Validation of the results and predictions will be done in Italy at the University of Trieste and in Finland at the Universities of Helsinki and Turku by using biobank samples, cell lines and experimental models. The test for drug response prediction will be developed by AB Analitica, an Italian SME.

Additional information:

www.project-hercules.eu
hercules@helsinki.fi

Tiia Pelkonen, Project manager
+358 50 3199520
tiia.pelkonen@helsinki.fi

Sampsa Hautaniemi, Project coordinator
+358 50 336 4765
sampsa.hautaniemi@helsinki.fi

Project partners

University of Helsinki, Finland
– Sampsa Hautaniemi
– Anna Vähärautio
– Tero Aittokallio
– Krister Wennerberg

Hospital District of South-West Finland
– Seija Grénman

University of Turku, Finland
– Olli Carpén

University of Trieste, Italy
– Giorgio Stanta

Istituto Superiore di Sanità, Italy
– Mauro Biffoni
– Luca Pasquini

Karolinska Institutet, Sweden
– Jussi Taipale

Institute Pasteur, France
– Benno Schwikowski

AB ANALITICA SRL, Italy
– Dino Paladin